Cardiac Hegemony of Senescence

From ‘theories of Hegemony’ to ‘hegemony Analysis’ in International Relations

Pharmacologic Inhibition of Cardiac Stem Cell Senescence

Mammalian aging may be viewed as a reduction in the capacity to adequately maintain tissue homeostasis or to repair tissues after injury(Sharpless and DePinho, 2007). When homeostatic control diminishes to the point at which tissue/organ integrity and function are no longer sufficiently maintained, physiological decline develops, and aging becomes apparent. Cells that express senescence markers...

The Hegemony of Play

In this paper, we introduce the concept of a “Hegemony of Play,” to critique the way in which a complex layering of technological, commercial and cultural power structures have dominated the development of the digital game industry over the past 35 years, creating an entrenched status quo which ignores the needs and desires of “minority” players such as women and “non-gamers,” Who in fact repre...

Cardiac Stem Cell Senescence in Ischemic Cardiomyopathy

We have recently demonstrated that human Cardiac Stem Cells isolated from explanted failing hearts (E-CSC) are characterized, in vitro, with respect to those isolated from healthy donors (D-CSC), by a senescent phenotype: a reduced telomere length and telomerase activity, telomere erosion, the occurrence of telomere dysfunction foci and the accumulation of senescent markers, as p16INK4A. In thi...

Cardiac Cell Senescence and Redox Signaling

Aging is characterized by a progressive loss of the ability of the organism to cope with stressors and to repair tissue damage. As a result, chronic diseases, including cardiovascular disease, increase their prevalence with aging, underlining the existence of common mechanisms that lead to frailty and age-related diseases. In this frame, the progressive decline of the homeostatic and reparative...